
Hi,
Error 0x80040154 (-2147221164), which indicates a class registration error, can indeed be encountered during Office 365 updates in SCCM (System Center Configuration Manager).
This issue has been reported by many users. The workaround you mentioned, running a script to re-register the Office components, is a common solution to address the issue after it has occurred.
Office 365 and SCCM are regularly updated, so it's essential to keep an eye on the latest information and documentation from Microsoft and the community for any new fixes or best practices that may have emerged.