Hi, @Menta Elise
Thank you for posting in Microsoft Q&A forum.
Yes, you can delete updates in WSUS using PowerShell. However, it's recommended to decline updates instead of deleting them to ensure there are no unforeseen consequences on the SCCM server's update management.
SCCM recognizes that declined updates no longer need to be installed on clients and won't deploy them unless they're approved again in WSUS. SCCM can also synchronize with WSUS and remove declined updates from its list of updates available for deployment.
If the answer is the right solution, please click "Accept Answer" and kindly upvote it. If you have extra questions about this answer, please click "Add comment".