Yes, you can. You can schedule a PowerShell script using Azure Automation to scale up the eDTUs and another one to scale down the eDTUs, Below, you will find how to scale up or down using PowerShell:
# Scale the pool
$elasticPool = Set-AzSqlElasticPool -ResourceGroupName $resourceGroupName `
-ServerName $serverName `
-ElasticPoolName $poolName `
-Edition "Standard" `
-Dtu 100 `
-DatabaseDtuMin 20 `
-DatabaseDtuMax 100
To get started with Azure Automation, try this short training.