@Kevin Redfern Thanks for reaching out to Microsoft Q&A, apologize for any inconvenience caused on this.
Based on the information shared, I have understood that you request to your Blazor is failing and you are seeing this error NS_ERROR_NET_PARTIAL_TRANSFER
message in the browser network trace and also you have mentioned that issue is self-resolved.
When I have researched about the error message all are pointing and this might be related to DNS issue. As you have mentioned that your webapp is configured with custom domain.
Could you please run the Binding & SSL configuration Detector in SSL and Domain category under Diagnose and Solve Problems of your webapp to check and eliminate whether are they any configuration issue.
As you are looking for root cause I would suggest you raise a support ticket to investigate deeper on this.
Feel free to reach back to me if you have any further questions on this.