Hi @pklong ,
Remote server returned '550 5.7.501 Service unavailable. Spam abuse detected from IP range.
Are you using the onmicrosoft.com domain name? Which is often used for testing, causing the recipient server's policy to block your IP address range. You can check suggestion provided in our official article Fix email delivery issues for error code 451 4.7.500-699 (ASxxx) in Exchange Online | Microsoft Docs.
To fix this issue your Tenant needs to be added to a sending exclusion for 60 days to allow them to use blocked IPs whilst they still have a new/trial license.
You can also submit a service request to Microsoft Support and provide a complete Non-Delivery Report (NDR). The Microsoft support team can help you remove your IP address from the blocked senders list.
(Please note that it may take up to 24 hours to remove all restrictions from the IP address)
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