Thanks for reaching out to Microsoft Q&A.
==>But the option "Enable management of the Office 365 Client Agent is greyed out?
Because the first setting "Enable software updates on clients" is set to No in your environment. If you change this setting to Yes, we can configure the "Enable management of the Office 365 Client Agent" settings now. As shown in my lab:
Thanks for your time. Have a nice day!
If the response is helpful, please click "Accept Answer" and upvote it.
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.