Hi @McGee, Lawrence E [SOFTWARE ENGINEER] ,
Please check the following posts if help:
https://social.technet.microsoft.com/Forums/en-US/72acf1d2-bcc9-46e4-b245-e52d754c7a77/biztalk-connection-issue-after-enabled-tls-12-and-disabled-lower-versions?forum=biztalkgeneral
https://social.technet.microsoft.com/Forums/fr-FR/5501c3d4-e74a-4c1b-8ff3-8e488fe4dd29/failed-to-load-group-biztalkmgmtdb-in-biztalk-2016-after-disabling-tls-10?forum=biztalkgeneral
BizTalk Server is currently not supported in the Q&A forums, you can ask the experts in the dedicated BizTalk Server forums over here:
https://social.msdn.microsoft.com/Forums/en-US/home?forum=biztalkgeneral
or
https://techcommunity.microsoft.com/t5/biztalk-server/bd-p/BizTalkServer
If the answer is helpful, please click "Accept Answer" and upvote it.
Hot issues in October—Users always get connection timeout problem when using multi subnet AG via listener. Especially after failover to another subnet