That would depend on the app (e.g. this would not work if the app is 16-bit). Have you considered trying App Compatibility Toolkit (https://learn.microsoft.com/en-us/windows/win32/win7appqual/application-compatibility-toolkit--act-)? App-V would require even more complex setup than you currently have - https://learn.microsoft.com/en-us/windows/application-management/app-v/appv-supported-configurations
hth Marcin