Yes it will. That isn't the issue here I believe. One thought that comes to mind is that your project is in a long directory and adding all this extra pathing is causing it to exceed the max path size.
Another thought is that there was an issue with downloading the package. Since you are targeting NET 4.6 it looks like then check your packages
folder to confirm it was downloaded. If not then restore the packages again.
Yet another thought is that your upgrading and there is a conflict between the old and new packages. Close VS, wipe the packages
folder and open VS back up and restore the packages again. Then try upgrading.