Hi,
These files are user profile disks https://learn.microsoft.com/en-us/windows-server/remote/remote-desktop-services/rds-plan-secure-data-storage. According to Microsoft recommendations and best practices, UPDs should be stored on a highly available storage outside of the RDS farm. You should reconfigure your RDS server to put those user profile disks on one of the following:
- Scale-out file server running locally on Storage Spaces Direct https://learn.microsoft.com/en-us/azure-stack/hci/concepts/storage-spaces-direct-overview or Virtual SAN https://www.starwindsoftware.com/vsan.
- Azure https://learn.microsoft.com/en-us/windows-server/remote/remote-desktop-services/rds-storage-spaces-direct-deployment.