@NIJSTEN Stephen Thank you for reaching out to us, as far i am aware - it's not possible to exclude arc enabled machines from defender for cloud.
MDFC is a subscription-level service. The only option would be a subscription where MDFC is disabled.
Azure Arc and Microsoft Defender for Cloud integration - https://learn.microsoft.com/en-us/azure/cloud-adoption-framework/manage/hybrid/server/best-practices/arc-security-center#:~:text=4c3d%2D847f%2D89da613e70a8%27-,Azure%20Arc%20and%20Microsoft%20Defender%20for%20Cloud%20integration,-After%20you%20successfully
Let me know if you have any further questions, feel free to post back.
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