Hello,
Thank you for posting in Q&A forum.
I think using DefenderUI is a good choice. It aims to improve Windows Defender and increase its efficiency by providing features that exist but are not displayed in Windows.
As for whether Defender UI can be used in Defender for Business, generally speaking, Defender for Business and Defender UI are compatible. Because DefenderUI is not a third-party antivirus program, but an enhanced feature provided for Windows Defender. You can try using DefenderUI in the Defender for Business environment, but it is best to conduct some testing before use to ensure that it is compatible with your environment and does not cause any conflicts.
Hope this answer can help you well.
Best regards,
Jill Zhou