@Cumbie, Keith,Thanks for posting in Q&A.
From your description, I know you want to know what will be impacted if TCP Port is blocked.
I have done some research, there are the affects will be.
1.Block users access websites hosted on servers using port 80.
2.Servers using port 80 may be unable to receive incoming requests
3.Disabling TCP port 80 affects Apple dependencies in addition to Intune Core Services, and Authentication dependencies.
4.It could affect diagnostics, reliability, and overall network performance.
Hope this can help you.
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