Hey there ssc
Thats a good question and thanks for using QandA platform.
I think yes, it is possible to set up a disaster recovery (DR) solution using Azure Managed Instance Link as the secondary site and an on-premises failover cluster with SQL Server 2022 Always On High Availability (HA) with multiple nodes as the primary site.
you can replicate databases across these nodes, bolstering data redundancy and facilitating failover within your on-premises environment. and, make an Azure SQL Managed Instance in Azure for disaster recovery purposes.
by using Managed Instance Link, you can securely connect your on-premises environment to Azure, enabling seamless data replication and failover capabilities. Implementing data replication mechanisms ensures continuous synchronization between your primary on-premises site and the secondary Azure site, minimizing potential data loss in case of a disaster.
If this helps kindly accept the answer thanks much.