Hi, @Anthony Vand
Thank you for posting in Microsoft Q&A forum.
Disabling SMBv1 on your SCCM server should not cause any issues as long as you have verified that there are no clients or applications that require SMBv1. SMBv1 is deprecated and considered a security vulnerability, so it is generally recommended to disable it if possible. You can disable SMBv1 on your SCCM server using the command you provided:
Set-SmbServerConfiguration -EnableSMB1Protocol $false
After running this command, you can verify that SMBv1 is disabled by running the following command:
Get-SmbServerConfiguration | Select EnableSMB1Protocol
If the output is "False", then SMBv1 is disabled on your SCCM server.
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