It is unlikely ntdll.dll. However that module is often in the callstack of errors because it is heavily used. Get the entire callstack for the crash. This will tell you what was going on at the time. Also, we have no visibility into what you're seeing so what is the actual error message involved? The more information you provide the better.
If it were a single machine then I'd lean toward a bad disk or memory. But if it is several then either network or something with the app. Without any error information it is hard to say.
If you can get a crash dump then that would be ideal. If the app crashes then Windows will generate one temporarily for you. If the app is hanging then you could use Process Explorer to generate a crash dump of the running process while it is hung.