Hi @Greg Booth,
Microsoft's official documentation does not indicate how the OOBC driver upgrade affects SharePoint Server. However, we recommend that you please do the following before upgrading:
1.Review the system requirements for both the ODBC driver (System requirements, installation, and driver files) and SharePoint Server 2016 (Hardware and software requirements for SharePoint Server 2016).
2.Ensure that your SharePoint environment is compatible with the new ODBC driver version.
3.We recommend that you back up your SharePoint environment before upgrading.
4.Test the upgrade in a non-production environment first to identify any potential issues.
5.Monitor your SharePoint environment for any unexpected behavior after the upgrade.
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