Hi @hampton123,
Under Developer portal - Frequently asked questions - Azure API Management | Microsoft Learn, when assigning a custom domain to the developer portal, you have to republish the portal for the changes to take effect. If you've already done this, try utilizing the troubleshooting guide, Azure API Management Diagnose and solve problems | Microsoft Learn, to identify and address the issue. Collecting a HAR trace file can help confirm if the issue is being caused by the domain assigned or an untrusted cert.
But you're still not able to determine the issue, please comment down below so we can more work more closely with you.