Hi Soar,
Thank you for posting on the Q&A Forum.
You can use NTFS permissions to restrict user access to locally stored OneDrive folders. This prevents users from saving data to the local OneDrive folder, but only to OneDrive in the cloud.
In System Settings, navigate to Apps->Startup and check OneDrive on the right side to set up a boot self-start.
All the best
Neuvi Jiang