I would ask Nutanix support.
Or download their resource doc:
https://www.nutanix.com/viewer?type=pdf&lpurl=optimizing-a-microsoft-exchange-deployment.html
Or ask on one of their blogs:
http://www.joshodgers.com/2018/07/31/predictable-scalable-ms-exchange-2016-performance-on-nutanix-with-ahv/