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Hi @Zhu, Ligong,
Unfortunately, profiles can't be deleted via registry settings. Removing the listed entries does not delete the profiles.
You can only remove the profile folders at %localappdata%\Microsoft\Edge\User Data.
Please note if you try to delete the folders while Microsoft Edge is running, you won't be permitted to do that. You need to kill all msedge.exe instances first. A useful command line would be taskkill /f /im msedge.exe
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Best Regards,
Shijie Li