If you do not have SSL Termination, you will need to check 2 main things to make sure that your setup is compatible:
1) Check your clients to make sure that they can connect using TLS 1.2 and the ciphers outlined. Both your OS and Browser might need to be configured to accept the connection.
2) If you are using End to End SSL, make sure that your backend server can accept the TLS 1.2 connections.
You can use SSL termination to rule out the backend, as the problem must be with the clients connecting.