The administration and maintenance of Microsoft Exchange Server to ensure secure, reliable, and efficient email and collaboration services across an organization.
Yes you can do that, go straight to CU18
Follow this and break out each step even if you are single domain/AD forest
https://learn.microsoft.com/en-us/exchange/plan-and-deploy/prepare-ad-and-domains?view=exchserver-2019
Then follow:
https://learn.microsoft.com/en-us/exchange/plan-and-deploy/install-cumulative-updates?view=exchserver-2019
NOTE:
Any customized Exchange or Internet Information Server (IIS) settings that you made in Exchange XML application configuration files on the Exchange server (for example, web.config files or the EdgeTransport.exe.config file) will be overwritten when you install an Exchange CU. Be sure save this information so you can easily re-apply the settings after the install. After you install the Exchange CU, you need to re-configure these settings.