Hello @EDWARD REYESARROYO
Thank you for reaching out to the Microsoft Q&A platform.
Regarding your question, enabling SMB signing by setting the EnableSecuritySignature registry value to 1 on the hosts should not affect profile redirection
Please take a look at the following paragraph extracted from The Basics of SMB Signing (covering both SMB1 and SMB2)
If you decide that you must change the SMB signing settings, the recommendation is to use the “Digitally sign communications (always)” Group Policy setting. If you cannot do it via Group Policy, you could use the “RequireSecuritySignature” registry setting.
IMPORTANT: We no longer recommend using “Digitally sign communications (if client agrees)” or “Digitally sign communications (if server agrees)” Group Policy settings. We also no longer recommend using the “EnableSecuritySignature” registry settings. These options, which only affect the SMB1 behavior, can be effectively replaced by the “Digitally sign communications (always)” Group Policy setting or the “RequireSecuritySignature” registry setting.
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