Have you changed password for service account or installed CU before?
Please check below tips to troubleshoot the issue.
1.Go to Services.msc -> Make sure the SharePoint Timer Service is running. And you use correct account and password to start the service.
2.Go to IIS -> If the error occurs when accessing the central administration, the SharePoint admin center v4 application pool may be stopped and needs to be started. If the error occurs when accessing the SharePoint site, the SharePoint – 80 application pool may have been stopped and needs to be started.
3.If the necessary application pools are started and the error persists, then you should check the application pool account in the IIS and the group membership of the group IIS_IUSRS.
(1)Go to IIS, check the account of the application pool in the identity column. Make sure you use correct account and password to start the application pool.
(2)Go to lusrmgr.msc -> Local Users and Groups a -> IIS_IUSRS. The application pool account must be a member of this group.
(3)Go to gpedit.msc -> Computer Configuration > Windows Settings > Security Settings > Local Policies > User Rights Assignment -> Verify that the IIS_IUSRS
group is included in the following policy: "Log on as batch job" and "Impersonate client after authentication".
4.Check ULS log file to check if there are any clues about this issue.
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