
Hi @Cross, Matthew [USA],
SPD Error: Microsoft SharePoint designer does not support editing non-SharePoint sites,To resolve this issue, you may want to try the following steps:
1.Check if client integration is enabled in Web Application settings from the Central Admin site.
2.If the above process couldn't help, you may refer to the following steps:
- Press Windows+R > enter regedit;
- Go to HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Common\Internet\WebServiceCache\AllUsers\office15client.microsoft.com,
- Delete all the subfolders of the ...\office15client.microsoft.com folder.
If the answer is helpful, please click "Accept Answer" and kindly upvote it. If you have extra questions about this answer, please click "Comment".
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.