@Octopi Nederland B.V Wow, thank you for including all of the details and troubleshooting steps that you have already tried. It seems like you have already tried the obvious methods to troubleshoot and have followed best practices when setting up the web app.
Troubleshooting performance issues in the cloud can be difficult as there are a number of issues that can impact performance and in many cases, there is not a performance SLA.
With that being said, one final thing that we suggest to you is to navigate to your web app in the Azure portal and select the 'diagnose and solve' blade of your web app. From there, run the 'availability and performance' test and then check the 'web app slow' results. Is there anything in there that stands out to you?
If not, then you have already gone through all the able approaches to troubleshooting performance that we can provide on the forum. If the diagnose and solve blade did not address the matter, please email me at azcommunity@microsoft.com with a subject of ATTN: Bryan and then in the body include your Azure Subscription ID and the URL of this post.
We look forward to your reply.