
Hi @O V, Naveen,
Unfortunately, currently Microsoft Edge and WebView2 does not have any setting, policy or registry for disabling certain kind of mouse click. If you would like to request such settings/policy, please consider sending feedback in Microsoft Edge at ··· menu --> Help and feedback --> Send feedback.
As a workaround, I'm afraid you'll need to disable the middle mouse click by JavaScript or scripts like AutoHotKey. Thanks for your understanding.
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Best Regards,
Shijie Li