Hello,
Running a full scan on servers consumes significant resources, including CPU and disk I/O, which may impact the performance of services running on those servers. It is recommended to schedule such scans during off-peak hours to minimize disruption. If your endpoints are connected to large shared network drives and you configure this scan this does impact the completion time of a full scan, making it take significantly longer due to the increased amount of data being scanned. You can refer to the following link.
If you are worried about the risks of mapping a shared network drive, Microsoft has a corresponding policy for this. You can refer to the following link for details.
Protect SMB traffic from interception | Microsoft Learn
Best Regards
Zunhui