Hi Tony Kostansek,
It sounds like the Group Policies being applied to the Windows 11 Pro PC are causing the issue with accessing applications and loading the desktop. You may need to review the Group Policies being applied to the PC and make sure they are not blocking access to applications or causing issues with the desktop. You can use the Group Policy Management Console to review and modify the Group Policies being applied to the PC. Additionally, you may want to check the event logs on the PC and the server to see if there are any errors or warnings related to Group Policy processing. If you are still having issues, you may want to consider reaching out to Microsoft support for further assistance.
Best regards,
Qiuyang