Hello KRGH NUSS,
Thank you for posting in Microsoft Community forum.
1.Are the user profiles you mentioned local user profiles or roaming profiles?
2.What changes have you made before the problem occurs?
3.Did the users sign in machines locally or remotely?
4.Could you please confirm, when the problem occurs, if the problem user changes one working machine to sign in, then check if the issue persists?
5.Could you please confirm, when the problem occurs, if the working user changes one problem machine to sign in, then check if the issue persists?
I hope the information above is helpful.
If you have any question or concern, please feel free to let us know.
Best Regards,
Daisy Zhou