Hello,
There are some details that we need to confirm with you so that we can accurately solve the problem:
Is there no response when you use the keyboard and mouse key combination? Does this phenomenon only occur in certain specific applications (a game or office software)? Does the mouse function normally when used alone?
You can first check that the new computer has all available driver updates and patches installed. In addition, you can use another mouse to test to rule out mouse hardware problems.
If the issue persists, please kindly provide more details.
Best regards