Hello,
Thank you for posting in the Microsoft community forum.
According to your description, the scanner is working on another computer, and you have verified the port configuration. The symptom appears to be specifically affected by your primary computer Settings.
Here are some other steps you might consider:
- Eliminate driver conflicts:
There may be driver conflicts or leftover files of previously installed drivers that can cause problems.
Uninstall the Epson 4990 driver. Download the latest available drivers from the Epson website.
During the installation process, right-click the installer and select Properties.
Go to the Compatibility TAB and try running the installer in compatibility mode with earlier versions of Windows.
- Refresh the USB controller:
Go to Device Manager > Universal Serial Bus Controller.
Right-click each item and select "Uninstall Device".
When you restart your computer, Windows should automatically reinstall the USB controller.
- Enable the safe mode and check whether the scanner is detected.
Please refer to this article for detailed steps: Windows startup settings - Microsoft Support
In the boot Settings list, use the number key 4 to enter safe mode.
In addition, check if the problem persists after a clean boot:
How to perform a clean boot in Windows - Microsoft Support
If so, the problem may be caused by third-party software or services operating in normal mode.
- Test with different user profiles:
Create a new user account on your Windows 11 computer and test to see if the scanner is detected under this new profile. This helps determine if the problem is related to your user profile Settings.
I hope this helps.
Best regards
Jacen