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Creating a single Application Gateway for Containers (AGC) in a hub to connect to multiple AKS clusters in a spoke is possible, but there are some limitations to consider:
Multiple Frontends: An AGC can support multiple frontends, allowing you to configure more than one web application on the same port. This enables multi-site hosting by using unique backend services for different environments.
Single Association: Currently, an AGC is limited to a single association. This means that while you can have multiple frontends, the AGC can only be associated with one subnet in a virtual network. This limitation might affect your ability to connect to multiple AKS clusters if they are in different subnets.
For more detailed guidance, you can refer to the Azure documentation on multi-site hosting with Application Gateway for Containers.
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Deepanshu