Hello Simon Bennetts,
Given that setup, the 530-User cannot log in error combined with the DCOM warning in the Event Viewer points to a permissions issue rather than a misconfiguration of the FTP site itself.
I would suggest you verify few below mentioned points since you are using IIS Manager users for FTP
First, make sure the IIS Management Service is installed and running. This service is required to support IIS Manager authentication. Then, allow the IIS Manager user access to the FTP site. In the FTP Authentication settings, make sure “IIS Manager Authentication” is enabled. If you’re not using Basic or Anonymous authentication, those can be disabled to avoid conflicts.
Now, about the DCOM error you’re seeing that’s a known issue in some FTP setups and can prevent authentication from completing.
To fix this, goto component services (dcomcnfg) and go to Computers > My Computer > DCOM Config.
Look for the application matching the CLSID in the Event Viewer warning.
Go to Properties > Security tab, and under “Launch and Activation Permissions,” click “Edit.”
Add NT AUTHORITY\SYSTEM and make sure it has both “Local Launch” and “Local Activation” permissions. Also check file system permissions for the folder. The IIS Manager user doesn’t map directly to a Windows account, but the FTP process still needs read/write access to the user’s folder. Usually, granting access to the IIS_IUSRS group or the Application Pool identity should cover this.
After all the above is verified, restart both the FTP service and the IIS Management Service
Restart-Service ftpsvc
Restart-Service wmsvc
Then try connecting again using FileZilla. Let me know how it goes. Thanks