Your question is not clear, are you asking if bidirectional replication is possible between on-premise and Azure?
- On-premise --> Azure
- Azure --> On-premise
With Azure Site Recovery (ASR) it is possible to replicate computers from on-premise to Azure, and then fail back the computers.
More information over at the Microsoft documentation:
If you have any questions related to ASR, you can reach out to the experts in the dedicated ASR forum over here: