Hi,
Please note remote desktop only supports sending / using absolute input modes instead of relative mode. When an application that uses relative modes tries to interpret the Remote desktop mouse input - the result is that you will get very large vectors.
But per searching, someone is investigating on this behavior and shared some workarounds to improve RDP's support on relative mouse movement.
Details could be found in below link:
Erratic mouse movement in 3D games over RDP with RemoteFX
https://superuser.com/questions/849918/erratic-mouse-movement-in-3d-games-over-rdp-with-remotefx
Hope this helps and please help to accept as Answer if the response is useful.
Thanks,
Jenny