Hi Hooterman23,
· Which version of windows are you using?
This problem occurs when Windows Installer encounters an error. Error code 0x80070643 and error code 0x643 are provided by Windows Installer. These error codes are generic errors that basically state that an error was encountered by Windows Installer.
You may try to download and install the latest windows installer on your computer and then try to install the updates.
Also reset windows update components. Open the link below and run the FIXIT.
tp://support.microsoft.com/kb/971058
Refer:
When you try to install an update for the .NET Framework 1.0, 1.1, 2.0, 3.0, or 3.5, you may receive Windows Update error code "0x643" or Windows Installer error code "1603"
http://support.microsoft.com/kb/923100
You receive error code 0x80070643 or error code 0x643 when you use the Windows Update or Microsoft Update Web sites to install updates
http://support.microsoft.com/kb/958052
Hope this helps.
Bindu R - Microsoft Support
Visit our Microsoft Answers Feedback Forum and let us know what you think.