Hi,
1. What happens when you try to open the C:/ drive?
2. Do you get any error message?
3. What is the complete and exact error message?
I would suggest you to perform a System Restore from safe mode to an earlier point of time before you encountered this problem.
If you need to changed the drive location then, I would suggest you refer MrFurry’s post in the following link and check if it helps.
Important: This section, method, or task contains steps that tell you how to modify the registry. However, serious problems might occur if you modify the registry incorrectly. Therefore, make sure that you follow these steps carefully. For added protection, back up the registry before you modify it. Then, you can restore the registry if a problem occurs. For more information about how to back up and restore the registry, refer the following article:
Back up the registry
http://windows.microsoft.com/en-us/windows7/Back-up-the-registry
Also refer the link for details regarding Program files(x86).