Hi,
1. Have you made any changes to your computer?
2. Are you referring to Disk Cleanup in Windows or Disk cleaner as a third party software program?
Incorrect registry permissions if any, would result in the error INF Install Failure. Reason: Access is denied.
Method 1:
Try to re-register the Windows Installer Service and then run the product again by following this step:
a. On the "Start" menu, click "Run:.
b. In the "Open" box, type "msiexec /unreg", and then press ENTER.
c. On the "Start" menu, click "Run".
d. In the "Open" box, type "msiexec /regserver", and then press ENTER.
Method 2:
I would also suggest you to follow the link and check.
How to use the System File Checker tool to troubleshoot missing or corrupted system files on Windows Vista or on Windows 7