Sharief,
I have the same issue with my mouse--i am not able to switch between right and left-handed use.
I do this often to balance out any chronic discomfort, etc.
I am running Windows 7, all up-to-date. Recently i decided to load the Windows Mouse and Keyboard Center from the update. I had delayed doing this for many weeks or months, knowing that Microsoft would likely screw something up, as they did royally with
Windows 8 program installation and access.
But my Ergo 4000 Keyboard Favorite buttons were no longer working consistently, and i decided to load this update to get that functionality back. The keyboard functionality was corrected.
However, as John mentioned above, the Mouse and Keyboard Center REPLACED the tab in the Mouse settings that allowed me to switch from right to left-handed mousing. It is nowhere to be seen.
I am planning to remove this update, but thought i would research first. Here we are.
Can you help me find a simple solution? (I am not interested in registry settings or anything but a simple Control Panel fix.)
Thank you,
apowell802