Replacing a Motherboard implies that many components on that motherboard are different and therefore require different drivers to control properly. Thus it is not expected that your original hard drive (with drivers loaded that match your old motherboard) would boot your system after you replace the motherboard.
The next question is what, exactly, is the "original win 7 DVD"? Is your system an OEM system (Dell, HP, Compaq, Acer, etc) and this is the DVD that came with that system with Windows 7 pre-installed? If so, you face the same problem -- as an OEM Windows license will die when your computer dies and OEM install disks will only contain drivers for components on the original motherboard hardware. In addition, the [OEM] Windows license is in some form tied to the original motherboard by the OEM manufacturer. Replacing a Motherboard is considered as a different computer so far as a Windows installation is concerned. If this is your case, you will need to purchase a Retail (Boxed) version of Windows 7 to install on your system.
If you have a Retail Win7 DVD, then it is possible that you will need to supply drivers to your specific hardware at some point early in the installation to match your hardware.
Providing some of these details would help.
HTH,
JW