Running the free edition of Malwarebytes would probably be a good start.
http://www.malwarebytes.org/mwb-download/var8/
Mark Russinovich's TechEd sessions on hunting down malware may be of some interest, but that depends on your personal skill level.
http://channel9.msdn.com/events/TechEd/Europe/2014/CDP-B373
Also, there are several helpful suggestions in this thread in the Viruses and Malware forum: