Sorry for the delay in reply, I've been interstate for the past week with only a laptop.
Since returning I've experimented with swapping primary/secondary monitors and with changing resolutions. I can't reproduce the problem until I uncheck the Control Panel / Display option "Let me choose one scaling level for all my displays". If that option is unchecked, no matter what mouse pointer size/scheme I choose and apply, the pointer remains at the default setting until I apply the workaround above of setting the monitors to duplicate and then back to extend.
I originally asked about the problem here: http://www.eightforums.com/general-support/60014-cannot-change-mouse-pointer.html, and you can see from the response that another user also encountered exactly the same problem with multiple monitors where one was a 4k monitor.