Yea thats not supported from the matrix you referenced:
https://learn.microsoft.com/en-us/Exchange/plan-and-deploy/supportability-matrix?view=exchserver-2019
So the question is will it work? Maybe... Not supported often means, "not tested". - and if something goes wrong, you will be told by support that its "not supported" :)
Personally, I would plow ahead. Now, you can rollback the DFL/FFL, sure, but that has its own risks as well...
The big thing is to get Exchange 2010 to SP3 plus the latest RU so you can run the Hybrid Wizard and move those mailboxes to 365.
You may run into errors when you run the Exch Upgrades or it may stop you, but then you at least know what you need to do and can plan B it.