I too uninstalled the game and reinstalled and was right back to the access denied message. THere were 25 updates too. I have no idea which one caused the problem.
I bought a lap top recently and the guy at the store told me that soon all pc's will not even have a cdrom. I asked about games and he said "steam". awesome. Now they get a complete monopoly on the games.
But, that shouldn't mean that my currrent systems should be unable to play cdrom games.
After running the compatibility check, the game still wouldn't work, so i selected the option to send microsoft the error report and then my pc tells me the problem is an "incompatible .exe". wat?!?
I think they screwed up big on the last security updates and i hope it gets fixed. I don't want to use steam just to play a 8 year old game and I am not repurchasing it!. I hate steam.