In-place upgrades are never recommended for a number of reasons.
If your installation media was a gold or RTM version then you'll need to install this set as a prerequisite. When 2012 R2 RTM'd the updates were called rollups and were not cumulative and they also had to be installed sequentially in correct order.
then at this point; or if you installed Windows Server 2012 R2 with Update then you can start using the cumulative updates here.
the latest SSU
followed by the latest Monthly Rollup
The latest always contains new fixes plus the previous monthly update.
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