You should assume that malware might have locked up Windows Defender – especially if the Local Group Policy Editor has actually been removed (it’s not included in the Home Version of Windows 10). However, local administrators do have full access to the Group Policy settings via the elevated (Administrator) command prompt (just copy, paste, and run (Enter) the appropriate command line):
Determine the current status of the Group Policy registry switch for Windows Defender:
REG QUERY "HKLM\SOFTWARE\Policies\Microsoft\Windows Defender" /v DisableAntispyware
Turn Off Windows Defender:
REG ADD "HKLM\SOFTWARE\Policies\Microsoft\Windows Defender" /v DisableAntiSpyware /t REG_DWORD /d 1 /f
Turn On Windows Defender:
REG DELETE "HKLM\SOFTWARE\Policies\Microsoft\Windows Defender" /v DisableAntiSpyware
As an alternative, you can use the Turn_On_Windows_Defender.reg file provided here:
https://www.tenforums.com/tutorials/5918-windows-defender-turn-off-windows-10-a.html
Turn_On_Windows_Defender.regis a trusted file, and this is all there is to it:
Windows Registry Editor Version 5.00
; Created by: Shawn Brink
; Tutorial: http://www.tenforums.com/tutorials/5918-windows-defender-turn-off-windows-10-a.html
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender]
"DisableAntiSpyware"=-
Of course, you should also scan with this set of trusted malware-removal tools in order to make sure that the PC is clean:
Kaspersky Virus Removal Tool:
http://support.kaspersky.com/viruses/kvrt2015
Emsisoft Emergency Kit:
http://www.emsisoft.com/en/software/eek/
Malwarebytes Anti-Malware (free version only):
https://www.malwarebytes.org/antimalware/
Eset Online Scanner:
http://www.eset.com/us/online-scanner/
Some other trusted third-party malware-removal tools are listed here:
GreginMich