Hi @Muhammad Khan ,
1.Create a CSV file in the same format as the screenshot below and fill in the recipients.

2.If you've enabled security defaults in your organization, SMTP AUTH is already disabled in Exchange Online. Run the following command to enbale the SMTP AUTH for the specific mailbox.
Set-CASMailbox -Identity <> -SmtpClientAuthenticationDisabled $false
3.Run the following command to make sure powershell is using TLS v1.2 and send email from specific mailbox:
[Net.ServicePointManager]::SecurityProtocol = [Net.SecurityProtocolType]::Tls12
$UserCredential1 = Get-Credential
Import-CSV "<Path toCSV file>" | Foreach {Send-MailMessage -To $_.EmailAddress -from <The sender email address> -Subject '<>' -Body '<>' -BodyAsHtml -smtpserver "smtp.office365.com" -usessl -Credential $UserCredential1 -Port 587}
Please noted that the Send-MailMessage cmdlet is obsolete. This cmdlet does not guarantee secure connections to SMTP servers. While there is no immediate replacement available in PowerShell, Microsoft recommend you do not use Send-MailMessage.
For more information you could refer to: Send-MailMessage and Enable or disable authenticated client SMTP submission (SMTP AUTH) in Exchange Online
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