
What is the Operating System version you are using for your SharePoint farm(s)?
Is it possible for you to test with “Open in Explorer” function with Internet Explorer directly on your SharePoint Server 2016 farm?
The problem is not with the version of SharePoint or Edge, but version of OS of your farm.
“Open in Explorer” function (without using OneDrive or Groove) requires Desktop Experience feature, which is not provided with a separate installation option on Windows Server 2016 and later.
When you install Windows Server 2016 using the Setup wizard, you can choose between Windows Server 2016 and Windows Server (Server with Desktop Experience). Without making a choice in the Setup wizard, Windows Server 2016 is installed; this is the Server Core installation option (without Desktop Experience feature).
See the reference here: Install Server with Desktop Experience.
If you are using Windows Server (Server with Desktop Experience), here is the document you can refer to for further troubleshooting: Troubleshoot "Open with Explorer" issues in SharePoint Online.
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